The main economic base of Northlands Dene First Nation is trapping and fishing. Some of the businesses located in the communityare:
- Northlands Dene First Nation Motel
- Henry Dantouze Coffee Shop
- Antsanan Pool Hall/Arcade
- David Dantouze Convenience Store
- School Bus
- Peter Ansanen Arcade Store
- Northern Store
- Joe Dantouze Convenience Store.